Serum Apolipoprotein Ai & B, Lipoproteins, Lipids Levels in Indian Patients with Angiographically Defined Coronary Artery Disease

The association serum lipids, lipoproteins, and apolipoproteins between angiographically defined coronary artery disease (CAD) was evaluated in 251 Indian men and women in order to assess the predictive power of apolipoproteins as a 'marker' of coronary artery disease (CAD). Patients with 70% or greater narrowing of at least one coronary artery or 50% stenosis of the left main coronary artery (n=234, CAD+) were compared to those with lesions of < 50% stenosis (n = 186, CAD-) for total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), high density lipoproteincholesterol (HDL-C), very low density lipoprotein (VLDL-C), triglycerides, apolipoprotein A-I, apolipoprotein B, and apolipoprotein A-I/B. Information on nonlipid risk factors was obtained from questionnaires. CAD+ compared with CADhad higher frequencies of diabetes (P=<0.001), hypertension ( P=<0.05), and smoking (P<0.001). CAD+ patients had higher plasma concentrations of apoB (145.57±18.52 vs. 93.22±9.11mg/dl, P<0.001), Apo AI decreased plasma concentration (89.90±19.26 vs. 131.01±22.55, P<0.001). Total cholesterol, TGs and VLDLchol, were found not significant after correction of age where as LDL-chol (P<0.001), and HDL-chol (P<0.001) had significant change. Ratio of Apo AI/Apo B had most significant decreased in CAD+ patients. Apo AI, Apo and ratio of Apo AI/Apo B showed the most significant relation with the number of stenotic vessels and was associated with CAD in the normolipidemic subgroup. In conclusion, by using multiple logistic regression analysis, and adjusting for age & other traditional lipid measures Apo AI, apoB and ratio of Apo AI/Apo B was superior to chol, LDL-chol, HDL-chol, TG, in discriminating between CAD+ and CAD-.